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The Intel® Quartus® Prime Pro Edition Handbook is now subdivided into more manageable user guides. You can select the topic of interest in the filters below to see all the relevant documents (User Guides, Application Notes, Release Notes and so on) associated with that topic. 

Getting Started with Intel® Quartus® Prime Software

Creating a New Project with Intel® Quartus® Prime Pro Edition Software
ModelSim*-Intel FPGA Edition Simulation with Intel Quartus Prime Pro Edition

 Introduction to the Early Power Estimator (EPE)

Scripting the Quartus Prime Design Flow

Intel Hyperflex™ FPGA Architecture Tips and Tricks

Introduction to Platform Designer (formerly Qsys)
Intel Stratix® 10 Critical Chain
Intel Stratix 10 Hyper-Retimer
Intel Stratix 10 Fast-Forward Compile